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Ships from U.S.A. |
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Third party tested |
Ships from U.S.A. |
Easy checkout process |
Third party tested |
Ships from U.S.A. |
Easy checkout process |
Third party tested |
Ships from U.S.A. |
Easy checkout process |
Third party tested |
Ships from U.S.A. |
Easy checkout process |
Third party tested |
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VIP-5MG
Original price was: $79.99.$59.99Current price is: $59.99.
RETA (GLP-3)
Price range: $89.99 through $249.99
ARA-290-10MG
Original price was: $69.99.$49.99Current price is: $49.99.
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Description
- ARA-290 selectively activates the IRR. This pathway triggers tissue protection, repair, and anti-inflammatory responses.
- Neuroprotection and Repair: Research indicates ARA-290 can stimulate the regrowth of small nerve fibers, making it a candidate for treating Small Fiber Neuropathy (SFN).
- Anti-Inflammatory Properties: It reduces the production of pro-inflammatory cytokines and suppresses spinal microglia responses, which are key drivers of chronic pain.
- Analgesic Effect: It may directly inhibit TRPV1 channels, which are involved in pain sensation, providing relief from mechanical hypersensitivity.
Clinical Applications and Status
- Sarcoidosis: The FDA has granted ARA-290 Orphan Drug and Fast Track designations for treating sarcoidosis-associated small fiber neuropathy.
- Diabetes: Studies have shown it improves neuropathic symptoms and metabolic control (e.g., HbA1c levels) in patients with Type 2 diabetes.
- Other Potential Uses: Investigations are ongoing for its use in treating acute kidney injury, depression, and even preventing Alzheimer’s disease progression through monocyte modulation.
- Administration: It is typically administered via subcutaneous or intravenous injection. Its half-life is very short—roughly 2 minutes intravenously and 20 minutes subcutaneously.
